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Korean Cell Line Bank
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JCRB Cell Bank
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European Collection of Authenticated Cell Cultures
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Servicebio Inc
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Stanmore Implants Worldwide Ltd
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Image Search Results
Journal: Journal of Translational Medicine
Article Title: SLC38A5 suppresses ferroptosis through glutamine-mediated activation of the PI3K/AKT/mTOR signaling in osteosarcoma
doi: 10.1186/s12967-024-05803-6
Figure Lengend Snippet: SLC38A5 is up-regulated in osteosarcoma and associated with a poor prognosis. ( A ) The expression patterns of SLC38A5 across various tumors in the TCGA dataset based on the TIMER database. ( B ) The relative mRNA level of SLC38A5 in tumor ( n = 12) and adjacent normal tissues ( n = 12) based on clinical samples. ( C ) The protein level of SLC38A5 was assessed in osteosarcoma tissues and adjacent normal counterparts using western blot. ( D ) The quantitative analysis of the western blot result. ( E-F ) The protein level of SLC38A5 in human osteoblastic cell (hFOB1.19) and osteosarcoma cell lines (HOS, Saos-2, MG63, U2OS, 143B). ( G ) The mRNA level of SLC38A5 in different cell lines. (H-I) Kaplan–Meier survival analysis of SLC38A5 in osteosarcoma based on the TARGET database ( n = 86) and GSE21257 dataset ( n = 53). The median value of SLC38A5 expression is the cut-off for high and low expression. Results from three independent experiments are summarized in a histogram format. * P < 0.05, ** P < 0.01, *** P < 0.001
Article Snippet: The human osteosarcoma cell lines HOS, Saos-2 and
Techniques: Expressing, Western Blot